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Sponsored AI AM CLAUDE, A Beginner's Guide: Learn the basics of working with AI AI AM CLAUDE, A Beginner's Guide: Learn the basics of working with AI

Author

Hui-Lei Yu

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Open access Sep 2026

Loop-Centric Engineering of Terminal Deoxynucleotidyl Transferase for Enhanced Catalysis of 3'-Modified Nucleotides.

Efficient enzymatic DNA synthesis requires terminal deoxynucleotidyl transferases (TdTs) that can accept reversibly blocked nucleotides, but improving wild-type enzymes has traditionally depended on labor-intensive screening. Here, we combine deep learning-based structure prediction with molecular dynamics simulations...

Kun Shi, An-Na Li, Jian-He Xu et al. · 0 citations
Aug 2026

Probing the Catalytic Promiscuity and Enhancing the Efficiency of CYP725A4 with a Taxadiene Substrate Mimic

The catalytic promiscuity of cytochrome P450 CYP725A4 severely impedes paclitaxel biosynthesis, as it generates taxadien-5α-ol (T-5α-ol) alongside numerous by-products. Despite diverse proposed mechanisms and the reported role of facilitator of taxane oxidation (FoTO1) in promoting T-5α-ol formation, conclusive evide...

Long-Hao Huang, Ming-Yuan Lai, Zi-Han Zhang et al. · 1 citation

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