TDP-43 Post-transcriptionally Regulates SLC7A7 to Promote Ferroptosis and Metabolic Dysfunction-Associated Steatohepatitis upon Arsenic Exposure.
Chronic exposure to sodium arsenite (NaAsO2) is a recognized environmental driver of metabolic dysfunction-associated steatohepatitis (MASH), yet the post-transcriptional regulatory mechanisms underlying this hepatotoxicity remain poorly understood. Here, we identify a novel pathway involving the RNA-binding protein TD...