High-Calorie Diet Aggravates Lipopolysaccharide-Induced Pulmonary Inflammation in Juvenile Mice: Association of Acetate-Mediated Macrophage Polarization with AMPK/YAP Signaling
Macrophage polarization is an important modulator of the progression, severity, and resolution of pediatric pneumonia. Acetate, a metabolite produced by the gut microbiota, serves as a key regulator of macrophage polarization. Evidence demonstrates that a high-calorie diet (HCD) lowers acetate levels, thereby aggravati...