Structural basis of QX007N neutralizing interleukin-33 for asthma and COPD treatment.
Interleukin-33 (IL-33), a member of the IL-1 cytokine family, is upregulated in various inflammatory and allergic diseases, including asthma and chronic obstructive pulmonary disease (COPD). In this study, we report the generation and functional characterization of QX007N, a humanized monoclonal antibody that specifica...