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EnSol is introduced, an environment-aware probabilistic framework for molecular solubility prediction that represents the solute and solvent as molecular graphs and learns separate representations for each before bringing them together through cross-attention to capture solute-solvent interactions.
This work demonstrates establishment of genome-wide NS-association without active transcription and establishes diverse and partially redundant NS-targeting activities, which may facilitate dynamic gene positioning at NS periphery for context-specific transcriptional responses.
Photobiocatalysis integrates enzymatic catalysis with photochemistry, enabling challenging radical transformations with high selectivity under mild conditions. Early developments in this field were largely driven by the discovery that enzyme-bound cofactors can form photoactive charge-transfer complexes with substrates...
Protein engineering appears to be entering a golden age, defined by a rapidly accelerating pace of progress, even as significant challenges in design, screening, and real-world application remain.
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