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Hui-Ming Ge

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Oct 2026

Cryptic Methylation Enables Amino-Maleimide Formation in Ligiamycin Biosynthesis

Maleimide is a rare but powerful pharmacophore in natural products, yet its biosynthetic logic remains poorly understood. Here, we elucidate the biosynthesis of ligiamycins, bacterial decalin–amino-maleimide metabolites from Streptomyces sp. NA07271. Genetic and biochemical studies revealed an unusual dispersed PKS–N...

Cheng-Yuan Yuan, Xiu-Xiu Ma, Zhen-Peng Mai et al. · 0 citations

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