AlphaGenome Atlas, released in September 2026, provides functional predictions for nearly all possible human single-nucleotide variants using the AlphaGenome Variant Impact (AVI) score. However, empirical thresholds relating AVI quantile rank (AVI_QUANTILE) to clinical variant classifications have not been established....
Complex diseases require therapeutic decisions that adapt as the disease evolves over time and in response to treatment. Current precision medicine remains largely centered on selecting an individual drug or predefined regimen from molecular characteristics measured at a particular time. The next evolution of precision...
Hui-Qi Qu, H. Hakonarson· Journal of Genome Biotechnol...· 0 citations
Biological validation analyses showed that SYCP3 depletion significantly reduced the invasive and migratory abilities of DU145 cells and increased their adhesion capacity, suggesting a role for SYCP3 in DNA damage response and genomic instability in PCa metastasis.
M. Rodrigo-Faus, I. Del Monte-Garcia, Marina Hermosilla-Trespaderne et al.· Scientific Reports· 0 citations
This review examines generative models for DNA, RNA, and protein sequence design, emphasizing how different model classes represent biological constraints, operate over discrete and continuous spaces, and integrate sequence, structure, and function.
