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Sponsored Artificial Intelligence: A Modern Approach, Global Edition Artificial Intelligence: A Modern Approach, Global Edition

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Hui-Qi Qu

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Review Open access Sep 2026

Polygenic risk scores in human genetics for study design discovery and translation

This review outlines four major PRS-informed design strategies: tail sampling based on PRS extremes; discordance sampling based on mismatch between phenotype and PRS-implied risk; conditional and stratified genome-wide association analyses using PRS to adjust for / partition background risk; and residual phenotype anal...

Hui-Qi Qu, H. Hakonarson · 0 citations

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