Author

Huiqing Zhan

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Preprint Oct 2026

PhySeqNet: physics-informed fluorescent foci detection for BARseq spatial transcriptomics

BARseq enables spatially resolved gene-expression profiling across intact tissue, but its sensitivity depends on accurate detection and decoding of dense fluorescent rolonies. Existing spot-calling approaches can be conservative where signals overlap, while supervised deep learning is limited by the lack of reliable ma...

Neha Goswami, John R. Hover, Renae Galluccio et al. · 0 citations

University of

These findings increase the confidence in the use of zebrafish as a model for human cancer in addition to providing the first comprehensive mapping of DNA methylation in the normal adult zebrafish liver.

Leda Mirbahai, Timothy D. Williams, Huiqing Zhan et al. · 0 citations