Hui-Shan He

Unveiling the post-translational landscape of Claudins: Orchestrators of barrier integrity, signaling, and disease through dynamic modifications.

Claudins are a core family of transmembrane proteins that constitute tight junctions. By interacting with other tight junction proteins, they build the cellular barrier. Claudin proteins are subject to multi-tiered regulation at the pre-transcriptional, transcriptional, and post-translational levels. Post-translational...