Hui-Ting Xu

Clinical activity of chidamide-containing regimens after prior PD-1-based therapy in two patients with microsatellite-stable metastatic colorectal cancer: a case series and narrative review

Background More than 90% of metastatic colorectal cancers (mCRC) are microsatellite-stable (MSS), an immunologically “cold” subtype characterized by low neoantigen burden, impaired antigen presentation, and poor responsiveness to immune checkpoint inhibitors (ICIs). Epigenetic aberrations—including aberrant DNA methyla...