A nutrient-sensing protease DegS suppresses biofilm formation in Vibrio cholerae via the CdgH–c-di-GMP–VpsR axis under nutrient limitation
Findings reveal DegS as a key upstream sensor that translates nutrient scarcity into a precise inhibitory signal via c-di-GMP-dependent transcription, providing new insights into the molecular basis of V. cholerae environmental adaptation and highlighting a potential target within its transmission chain.