Selective discrimination of glycosaminoglycans (GAGs) is crucial for drug safety and quality control but remains challenging because GAGs share similar disaccharide repeating units and overlapping polyanionic features. Nanozyme-based sensor arrays offer a cross-reactive fingerprinting strategy, yet many require multi...
Si-Jie Li, Qing Cheng, Qi Sun et al.· Analytical Chemistry· 0 citations
Chemoresistance and dose-limiting toxicity remain major challenges in cancer chemotherapy, largely driven by aberrant activation of the protein kinase B (AKT) survival pathway. Although small-molecule AKT inhibitors can enhance chemosensitivity, their systemic activity frequently disrupts normal metabolic processes and...
Qi Fang, Xiao-Jun Zhang, Chong-Bo Ma et al.· ACS Nano· 0 citations
The lack of vascular and neural innervations in cartilage often results in poor drug delivery and penetration, compromising the efficacy of current therapeutics. To tackle this clinical challenge, we designed positively charged manganese-doped CeO2 nanozymes that combine reactive oxygen species (ROS)-scavenging activ...