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Sponsored AI AM CLAUDE, A Beginner's Guide: Learn the basics of working with AI AI AM CLAUDE, A Beginner's Guide: Learn the basics of working with AI

Author

Hui-Wen Lo

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2 papers indexed here

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Review Open access Nov 2026

Cyclin-Dependent Kinases 4/6 Inhibition in Glioblastoma: From Molecular Rationale to Therapeutic Challenges and Opportunities

Glioblastoma (GBM) remains the most lethal primary malignant brain tumor in adults despite maximal resection, radiotherapy, and temozolomide. The cyclin D-CDK4/6-RB axis plays a significant role in cell cycle regulation and is amongst the most frequently dysregulated pathways in many cancers including GBM, thus providi...

Ankush Chandra, Mariana K. Najjar, Phi-Long Tran et al. · 0 citations
Open access Sep 2026

SERINC2-mediated phosphatidylserine remodeling activates protrusion-localized AXL signaling to promote brain metastasis

SUMMARY Cell protrusions (CPs) promote metastasis by coordinating cell invasion, matrix remodeling, and communication with the microenvironment. The receptor tyrosine kinase AXL, activated in brain-tropic metastatic cancers, frequently localizes to CPs. The metabolic cues regulating CP biogenesis and AXL activation rem...

Zhi-Bo Yan, Maja Beus, Zhan-Nan Han et al. · 0 citations

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