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Open access Sep 2026

Aspirin suppresses cytoprotective autophagy and colorectal tumorigenesis through HSP90AA1 K410 acetylation-mediated ULK1 ubiquitination and degradation

Colorectal cancer (CRC) remains a significant global health challenge with high recurrence rates despite therapeutic advancements, underscoring the urgency for innovative therapeutic strategies. Clinical trials have demonstrated that aspirin treatment correlates with reduced cancer incidence, recurrence, metastasis,...

Fang Wang, Yu-Huan Zhang, Xing-Chen Dai et al. · 0 citations
Open access Sep 2026

Isoliensinine Suppresses Colorectal Tumorigenesis by Targeting PPP2R1A to Activate AMPK Signaling Pathway

Colorectal cancer, characterized by its invasive behavior, frequent recurrence, and limited responsiveness to standard treatment, necessitate the advancement of innovative therapeutic approaches. Isoliensinine (ISO), a natural bisbenzylisoquinoline alkaloid, has demonstrated broad antitumor activity. However, its e...

Hui Yan, Yi Huang, Xin-Ye Zheng et al. · 0 citations

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