Author

Hui-Yan Li

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Open access Aug 2026

Isoflavones with Multifaceted Activities Synergistically Sensitize Pseudomonas aeruginosa to Antibiotics In Vitro and In Vivo

Background/Objectives: Pseudomonas aeruginosa is a notorious multidrug-resistant pathogen that causes serious acute and chronic infections by employing quorum sensing (QS)-regulated virulence, biofilm formation, and host-damaging inflammation. To overcome the yield limitation of two previously identified marine seconda...

Dan-Dan Li, Tong-Hong Xia, Xin-Ya Zhang et al. · Antibiotics · 0 citations

Open access Aug 2026

A quorum sensing antagonist with dual bacterium- and host-directed anti-pathogenic activity against Pseudomonas aeruginosa

It is demonstrated that Spongosorites sp-derived bisindole alkaloid (R)-6’-debromohamacanthin B (RDB) exerts dual bacterium-directed and host-directed activities, simultaneously attenuating virulence and biofilm formation while reinforcing host defense and controlling pathological inflammation.

Dan-Dan Li, Hui-Yan Li, Wen-Bo Niu et al. · Virulence · 0 citations