Author

Hui Zhang

2 papers indexed here

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Open access Sep 2026

Immunoinformatics-Guided Design, Immunological Evaluation, and Macrophage Transcriptomic Profiling of a Multi-Epitope Vaccine Candidate Against Mycobacterium avium subsp. paratuberculosis

Mycobacterium avium subsp. paratuberculosis (MAP) causes Johne’s disease in ruminants and is difficult to control once persistent infection is established. We designed a MAP multi-epitope vaccine candidate by screening conserved proteins and assembling predicted B-cell, MHC class I-restricted cytotoxic T lymphocyte (CT...

Zhi-Jie Luo, Zeng-Ke Wei, Jia-Luo Xu et al. · Microorganisms · 0 citations

Open access Jul 2026

Brucella effector protein BspJ inhibits the NF-κB signaling pathway by targeting the Zfp740 promoter region to promote bacterial survival within macrophages

This study systematically elucidates a novel regulatory axis, BspJ-Zfp740-P65/NF-κB, and reveals a new mechanism by which Brucella directly interferes with host transcriptional programs through a nucleus-targeting effector protein to suppress inflammation and establish persistent infection.

Wen-Jia Wang, Xiaoxiao Cheng, Qianyi Zhang et al. · Animal Diseases · 0 citations