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Hui-Zhen Zou

1 paper indexed here

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Open access Sep 2026

Anti-CTLA-4 antibody potentiates the antitumor effect of armed oncolytic virus OVM18 via enhancing intratumoral IL-18R1+CD8+ T cells

Abstract Background Oncolytic virus M1 encoding a mutant IL-18 decoy (OVM18) represents a novel virotherapy that integrates selective oncolysis with localized activation of the IL-18 pathway. However, the heterogeneity of therapeutic responses suggests that host immune determinants influence its efficacy. Methods To el...

Xue-Ying Lin, Ji-Fu Zhang, Zhen Fan et al. · 0 citations

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