Hui Zong

Mouse genetic mosaic model for basal-like breast cancer reveals disruption of basal-myoepithelial architecture at premalignancy

In early cancer evolution, mutant cells must escape tissue-architectural constraints before progressing to malignancy. In the case of invasive breast cancers, loss of integrity of the wildtype basal-myoepithelial layer that wraps around premalignant luminal cells precedes the formation of an invasive tumor mass. The sp...