A comprehensive and updated synthesis of Polθ's structural architecture, regulatory networks, and context-dependent functions across major malignancies, including ovarian, breast, lung, and colorectal cancers, and a critical evaluation of current Polθ inhibitors.
Ming-Dian Lei, Yuxuan Li, Zhi-Peng Xie et al.· Biochemical and Biophysical...· 0 citations
It is suggested that DCHP may impair innate immune function through transcriptional alterations in immune- and stress-response pathways, although direct pathway activation or inhibition was not demonstrated.
Yuxuan Li, Siyuan Luo, Ming-Dian Lei et al.· Toxics· 0 citations
A theranostic platform HSF, featuring integrated tumor-specific near-infrared fluorescence imaging and photodynamic ROS generation for real time monitoring and targeted radiotherapy of solid malignancies for NPC, offering a transformative approach for real time visualization-guided NPC therapy.
Fan Zheng, Yan Mo, Jin Zhou et al.· Small· 0 citations
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