Open access
Sep 2026
mRNA-encoding CD19-targeting T cell engager for refractory immune thrombocytopenia.
While T cell engagers (TCEs) and chimeric antigen receptor (CAR)-T cell therapy show clinical promise for B cell depletion, challenges regarding safety, efficacy, and durability persist. ABO2203 is a lipid nanoparticle-formulated messenger RNA (mRNA) encoding a CD19-targeting TCE. In transgenic mice, ABO2203 induced co...
Meng-Yan Wang, Ting-Ting Liu, Qi Dai et al.
· Cell · 0 citations