Aug 2026
PARP7 Enhances Doxorubicin-Induced Cardiomyocyte Ferroptosis and Cardiotoxicity by ADP-Ribosylation-Dependent Suppression of GPX4 Activity.
It is demonstrated that PARP7 is robustly and selectively upregulated in cardiomyocytes following DOX exposure, and the PARP7-GPX4 axis is defined as a mechanistically grounded, therapeutically targetable pathway in cardio-oncology.
Yiting Lyu, Lin-Tao Wang, Xiao-Wen Shi et al.
· Translational Research: The... · 0 citations