Total flavonoids from Ageratum conyzoides synergize with docetaxel to induce ferroptosis in prostate cancer cells via the NRF2/SLC7A11/GPX4 signaling pathway.
TFG enhances the antitumor effect of DTX in prostate cancer cells by inhibiting the NRF2/SLC7A11/GPX4 axis, inducing lipid peroxidation, and triggering mitochondria-associated ferroptosis, providing a strong mechanistic rationale for developing TFG as a natural chemosensitizer for prostate cancer therapy, particularly...