Apelin-13 drives VSMC proliferation and atherosclerosis through REEP5-dependent disruption of ER-mitochondria coupling and glycolytic shift.
Atherosclerosis is characterized by pathological vascular smooth muscle cell (VSMC) proliferation and metabolic dysregulation, yet the underlying mechanisms remain incompletely understood. Here, we identified receptor expression enhancer protein 5 (REEP5) as a potential regulator of VSMC proliferation in atherosclerosi...