Jul 2026
Youthful-state extracellular vesicles for targeted therapy of intervertebral disc degeneration: resolving inflammation and pyroptosis through NF-κB suppression and NLRP1 inactivation
It is demonstrated that youthful-state EVs (Y-EVs) outperform aged donor-derived EVs (O-EVs) in resolving inflammatory cascades within nucleus pulposus (NP) cells and establishes CD55 as a key determinant of their therapeutic superiority.
Zhi-Wei Liao, Kun Wang, M. Lei et al.
· Biomedical Materials · 0 citations