M-SYFSF attenuates diabetic kidney disease by suppressing Piezo1-associated cGAS-STING signalling and tubular pyroptosis.
BACKGROUND Diabetic kidney disease (DKD) is a major cause of chronic kidney disease (CKD) worldwide, characterised by tubular injury, inflammation, and fibrosis. Increasing evidence suggests that mechanotransduction and innate immune activation contribute to DKD progression. However, the mechanistic link between mechan...