Dual-strategy; complexation-based solid dispersion for enhancing the solubility and dissolution rate of candesartan cilexetil
Background and objective: Candesartan cilexetil (CC), an angiotensin II receptor blocker indicated for hypertension and heart failure, is classified as a BCS Class II drug which is characterized by low aqueous solubility (0.963 ± 0.062 µg/mL) and limited oral bioavailability (14%–40%). Both factors significantly underm...