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Hung-Yu Chen

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Review Open access Aug 2026

[IUPHAR review] Resistance to PD-1/PD-L1 blockade: mechanisms and pharmacological strategies.

Immune checkpoint inhibitors (ICIs) targeting the PD-1/PD-L1 axis have transformed the realm of cancer treatment. Nevertheless, fewer than one in five patients derive durable benefit, and a substantial proportion of initial responders eventually relapse, reflecting a heterogeneous milieu of intrinsic and acquired mecha...

A. Kim, Nawon Lee, Hung-Yu Chen et al. · 0 citations

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