Metagenomic Search Reveals S. Enterica Protein with Structural Similarity to C. Difficile Toxin A
Clostridioides difficile infection (CDI) causes thousands of deaths a year in the United States. The symptoms of CDI are shown to be primarily attributed to the glycosyltransferase activity of toxin A (TcdA) and toxin B (TcdB). While this mechanism is well-characterized in C. difficile, similar glycosyltransferases in...