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Huohuo Xue

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Review Open access Sep 2026

Macrophage-driven pathological ossification of the posterior longitudinal ligament: mechanistic insights and therapeutic opportunities

Ossification of the posterior longitudinal ligament (OPLL) is a chronic degenerative spinal condition in which bone gradually forms within the ligament, compressing the spinal cord and causing progressive neurological decline. While genetic predisposition and metabolic disturbances are well-recognized contributors, gro...

Huohuo Xue, Tsutomu Endo, Ken Kadoya et al. · 0 citations

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