Husnul Fuad Zein

Early structural tendencies differ among amyloid beta 14 to 23 hexamers with F20P and E22A D23A substitutions

Short amyloid-β fragments provide controlled systems for examining how local sequence chemistry influences early structural behavior. For each sequence, we analyzed three 100-ns velocity-replicate all-atom molecular dynamics trajectories for six-peptide Aβ(14–23) systems of wild type (WT), F20P, and E22A–D23A. During 8...