Open access
Aug 2026
Neddylation of NFATc1 and Runx2 regulates osteoclast–osteoblast balance and represents a dual-action therapeutic target for postmenopausal osteoporosis
The study reveals that neddylation stabilizes NFATc1, promoting osteoclastogenesis, while destabilizing Runx2, suppressing osteoblast maturation, and reveals its potential as a mechanism-driven dual-action therapeutic target for PMOP.
Joo-Yang Lee, Min Young Lee, Hong Seok Kim et al.
· Experimental and Molecular M... · 0 citations