Biosynthesis of 4-hydroxyvalerate from glycerol in engineered Pseudomonas putida KT2440 and its application for the production of Poly(3-hydroxybutyrate-co-3-hydroxyvalerate-co-4-hydroxy valerate) (P(3HB-co-3HV-co-4HV)) terpolymer.
The 4-hydroxyvalerate (4HV) is a key intermediate that serves as a precursor for γ-valerolactone (GVL) and terpolymers, contributing to the synthesis of liquid fuels and biodegradable plastics with improved properties. While 4HV is typically derived from levulinic acid (LA) via chemical catalysis, these methods are lim...