Review
Open access
Aug 2026
Emerging roles of granzymes in neurodegeneration and neuroinflammation: mechanistic insights and therapeutic opportunities
GzmB is the most extensively characterized, with evidence supporting both intracellular neurotoxicity and extracellular pathogenic functions mediated through protease-activated receptor signaling, ECM cleavage, outer blood–retina barrier disruption, angiogenesis, fibrosis, and chronic inflammation.
Hyung-Suk Yoo, Philip Yu, Ceres Zhou et al.
· Acta Neuropathologica · 0 citations