Developing a strain‐dependent susceptibility to hepatocellular carcinoma in a murine model based on histopathological evidence and genetic context
Abstract Hepatocellular carcinoma is a leading cause of cancer‐related mortality worldwide. Smad4, a well‐established tumor suppressor within the transforming growth factor‐β (TGF‐β) signaling pathway, has an oncogenic potential of its heterozygous loss, still poorly defined, especially across genetically diverse backg...