I. Amit

A single-cell atlas of multiple myeloma defines malignant archetypes and proliferative states

CytoVI: deep generative modeling of antibody-based single cell data.

Antibody-based single-cell technologies, such as flow cytometry, mass cytometry and CITE-seq, have become widely used in clinical diagnostics and basic research; however, their analysis is complicated by technical noise, batch effects, platform differences and restricted antibody panels. Here we present CytoVI, a proba...

SALL1 and neural microenvironmental context specify identity of stem cell derived human microglia-like cells

Microglia, the immune cells of the brain parenchyma, play a pivotal role in neurodevelopment and neuroprotection. Human stem cell-derived microglia-like cells (MGL) offer a valuable, human-relevant system to study microglia in vitro. However, their cell states and intercellular interactions within complex 3-dimensional...