Author

I. Cózar-Castellano

2 papers indexed here

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Open access Sep 2026

Primary cilia coordinate c-KIT signaling induced proliferation in alpha cells

Circulating glucagon levels are elevated in patients with diabetes and obesity and contribute to hyperglycemia. The mechanisms underlying hyperglucagonemia remain poorly understood, but expansion of pancreatic α-cell mass is thought to play an important role. Primary cilia are sensory organelles that act as signaling h...

Ganga Deshar, Mariam G. Aslanyan, Gaurav D. Diwan et al. · bioRxiv · 0 citations

Open access Oct 2026

Aging Affects Pancreatic α‐Cell Function and Promotes Hyperglucagonemia: Implications in Age‐Associated Diabetes

ABSTRACT Aging is a major risk factor in the development of type 2 diabetes mellitus (T2DM). With age, pancreatic β‐cells undergo functional and cell identity changes that can compromise insulin secretion, thereby contributing to impaired glucose tolerance and T2DM. However, glucose homeostasis also depends on pancreat...

E. Tudurí, Lucía Almagro, Ana Ojeda-Rodríguez et al. · Aging Cell · 0 citations