Author

I. D̵ikić

2 papers indexed here

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Open access Sep 2026

Programmed ribosomal frameshifting triggers translational stress to promote viral replication.

Programmed ribosomal frameshifting (PRF) is a conserved viral strategy for expressing polyproteins from compact genomes. Although PRF is traditionally viewed as a structural mechanism, here we show that it functions as a regulatory signal that rewires host translation in favor of viral replication. A minimal SARS-CoV-2...

Audrey Xavier, Melinda Kolling, Ashley M. Bourke et al. · Cell · 0 citations

Nov 2025

Vitamin B12 alleviates spliceosomopathy via phospholipid remodeling

Spliceosomal dysfunction profoundly impacts cellular metabolism, yet mechanistic links between RNA splicing defects and metabolic rewiring remain limited. Here, we investigate Verheij syndrome (VRJS), a rare disease caused by mutations in the core splicing factor PUF60. Using a Caenorhabditis elegans model, human cell...

A. Antebi, Wenming Huang, Jonathan Kölschbach et al. · Research Square · 0 citations