Author

I. Forné

2 papers indexed here

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Open access Aug 2026

RNA-dependent association of the pyruvate dehydrogenase complex with mtDNA-containing assemblies supports mitochondrial translation

Mitochondrial DNA (mtDNA) encodes core subunits of the oxidative phosphorylation machinery, and its expression is spatially organized, with the genome packaged into nucleoids around which transcription and mitoribosome assembly are concentrated. How this architecture is built, and how it is linked to the metabolic stat...

Johannes Hagen, Nupur Sharma, Felix Thoma et al. · bioRxiv · 0 citations

Open access Jul 2026

Identifying critical lysines in mammalian histone H3 with high-throughput CRISPR prime editing.

Histone post-translational modifications are fundamental to genome regulation, yet dissecting the functions of individual histone marks in mammals remains challenging due to the presence of multiple histone gene copies. Here we develop a high-throughput clustered regularly interspaced short palindromic repeats (CRISPR)...

Daniel Price, Grigory Zemlyanskiy, Watanya Trakarnphornsombat et al. · Nature Genetics · 0 citations