Author

I. Ilie

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Open access Sep 2026

Physical mechanisms of nanoparticle intracellular release through membrane pore nucleation and expansion

Successful intracellular delivery requires a nanocarrier to adhere to the cell membrane, be wrapped and internalized and finally released into the cytoplasm before it is degraded. While the initial steps have been intensively studied, the intracellular release of a nanocarrier has received comparatively less attention...

Massimiliano Paesani, I. Ilie · bioRxiv · 0 citations

Open access Sep 2026

Remote Residue Substitution and Macrocyclization Preorganize a β‐Hairpin Peptide and Enhance β‐Catenin Binding

Peptide‐based inhibitors are promising tools to target challenging protein interfaces, yet improving their affinity and drug‐like properties is still a major hurdle. This holds particularly true for β‐sheet motifs with only limited strategies available to robustly stabilize their conformation. Previously, we reported l...

Michael H. N. Meulendijks, Yun Li, Frederik J. Steiner et al. · ChemistryEurope · 0 citations

Open access Jul 2026

Computationally engineered cyclic peptides reduce prion levels in vitro

These results establish a mechanistic link between peptide-induced stabilization of PrPc and inhibition of prion propagation and provide a generalizable framework for designing conformational stabilizers of aggregation-prone proteins.

Elpiniki Paspali, C. Morales, Daria De Raffele et al. · bioRxiv · 0 citations