Spatial Transcriptomic Profiling of FAP-Positive Cells in Gastric Cancer and Association with Immunotherapy Efficacy.
INTRODUCTION The spatial heterogeneity of the tumor microenvironment in gastric cancer, particularly in the stromal compartment, remains poorly characterized. Fibroblast activation protein (FAP)-positive cancer-associated fibroblasts (CAFs) are known to promote tumor progression, immune evasion, and therapeutic resista...