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Author

I. Lee

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Review Open access Aug 2026

A proposed evaluation of new approach methodologies for dermal toxicity assessment of botanicals

Abstract Background Botanicals are widely used in topical formulations for cosmetics, hair care, and personal care products, reflecting consumer interest in plant-derived materials. Their complex and variable composition, presents challenges for traditional toxicological approaches developed for single chemicals. Altho...

J. Krzykwa, Allison Hilberer, Karin Ames et al. · 0 citations
Review Open access Sep 2026

Strategic Application of New Approach Methodologies (NAMs) in Fragrance Ingredient Safety Assessment: Integration of In Vitro, In Silico, and Exposure-Based Approaches in RIFM Evaluations.

New Approach Methodologies (NAMs) are transforming toxicological risk assessment by providing human-relevant, non-animal approaches for hazard identification, exposure assessment, and safety evaluation. This manuscript presents an overview of the Research Institute for Fragrance Materials (RIFM) New Approach Methodolog...

I. Lee, A. Api, A. Bartlett et al. · 1 citation

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