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I. Miliukhina

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Sep 2026

mTOR and STING Modulation Restores Hydrolase Activities and Decreases Alpha-Synuclein Pathology in the Cells from the Patients with GBA1-Associated Parkinson’s Disease

Findings identify mTOR and STING as central regulators of lysosomal functioning and GCase activity in the GBA1-PD, acting through the distinct but partially overlapping mechanisms.

T. Usenko, A. Bezrukova, K. Basharova et al. · 0 citations
Aug 2026

GCH1 genetic variation as a prognostic factor in Parkinson disease across populations

GCH1 pathogenic variants were associated with a clinically distinct phenotype characterized by earlier disease onset and slower progression of motor complications, suggesting that GCH1 genetic variants may serve as genetic biomarkers for patient stratification and prognosis in PD.

J. Shin, M. T. Periñán, J. W. Jang et al. · 0 citations

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