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Author

I. Panaccione

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Open access Sep 2026

Reduced Anticipatory Pleasure in Early-Onset Severe Cannabis Use Disorder: A Retrospective, Cross-Sectional Study

Background: Cannabis is the most widely used illicit substance, particularly among youth. Earlier onset is associated with poorer clinical trajectories in cannabis use disorder (CUD), but its relationship with hedonic–motivational components remains unclear. Methods: Outpatients with severe CUD (n = 121) were stratifie...

M. Pepe, Francesco Traccis, G. Mandracchia et al. · 0 citations
Review Open access Aug 2026

Evaluating seltorexant as a treatment option for major depressive disorder

Seltorexant 20 mg has shown a promising antidepressant effect, particularly in patients with clinically significant insomnia, and a favorable tolerability profile, and the mixed phase-3 results, the modest effect sizes, and gaps on core symptoms of depression warrant a measured positive view, pending confirmatory data.

M. Di Nicola, M. Pepe, I. Marcelli et al. · 0 citations

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