RETHINKING AEROBIC METABOLISM IN RETINAL ROD OUTER SEGMENTS: TRIPLE METABOLIC HYPOTHESIS AND CLINICAL IMPLICATIONS.
The vertebrate retina is among the most energy-demanding tissues in the body, with photoreceptors accounting for most of its metabolic activity. The photoreceptor outer segment, devoid of mitochondria, carries out visual transduction. Oxidative phosphorylation in the rod inner segment has been considered the primary so...