Classic myeloproliferative neoplasms, including essential thrombocythemia, polycythemia vera, and primary myelofibrosis, are chronic, clonal hematopoietic stem-cell disorders driven by gain-of-function mutations in the genes Janus kinase 2, CALR, or the thrombopoietin receptor that activate cytokine signaling.
I. Plo, W. Vainchenker· New England Journal of Medic...· 0 citations
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