I. Rabiner

577. **Rafaelsen Award Presentation** Association between cortical serotonin release and cognitive function in schizophrenia: an in vivo [11C]Cimbi-36 PET study with a d-Amphetamine challenge

Abstract Background Cognitive symptoms of schizophrenia are highly disabling. There are no licensed treatments and the underlying neurobiology is unclear. Indirect evidence implicates abnormalities in cortical serotonergic neurotransmission, but no prior study has tested if cortical serotonin release is associated with...