The cGAS-STING pathway is a fundamental cytosolic DNA-sensing mechanism that activates innate immune responses through the production of type I interferons (IFNs) and other cytokines. Autophagy, a conserved intracellular degradation system, plays crucial roles in maintaining cellular homeostasis by clearing damaged o...
Dan-Dan Ye, Qiong Li, Amit Sharma et al.· Molecular Medicine· 0 citations
Introduction While genetic abnormalities underlying lymphoid malignancies (LM) are well-characterized, the environmental and metabolic determinants driving LM remain largely unexplored. Autoimmune diseases are known risks, yet the specific circulating mediators and potential protective dietary factors linking these con...
Dong-Guo Liang, Yan Ren, Yu-Qi Feng et al.· Frontiers in Immunology· 0 citations
Unraveling the intricate mechanisms of EMT activation in cancer will contribute to the advancement of personalized medicine and the design of more effective treatments against metastatic disease and pave the way for advancements in personalized medicine and improved treatment strategies for patients affected by EMT-rel...
Vafa Meftahpour, T. C. Dakal, Jarek Maciaczyk et al.· Signal Transduction and Targ...· 0 citations
This review comprehensively highlights the latest advancements in using nanotechnology to enhance cancer immunotherapy and highlights synergistic effects achieved by combining nanoparticles with other treatments like chemotherapy, radiation, photothermal/photodynamic therapy, and more, which can turn hard-to-treat tumo...
U. Cho, Jing-Jing Pu, Amit Sharma et al.· Molecular Cancer· 0 citations
The mechanisms through which glioblastoma is initiated, localized, and eludes therapy responses are summarized and an update is provided on recent advances made within this therapeutic space to overcome GBM‐mediated immunosuppression.
Emerson Achari, Farah Ahmady-Nield, Amit Sharma et al.· Immunology and Cell Biology· 0 citations
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