Aug 2026
Clinical Heterogeneity of TNFRSF13B Variants: A Monogenic Cause or a Genetic Modifier?
Patients with TNFRSF13B variants display broad phenotypic heterogeneity ranging from asymptomatic carriage to CVID and combined immunodeficiency phenotypes, suggesting that coexisting genetic variants and exposomal factors likely determine the clinical expression and disease severity.
Begum Cicek, Deniz Ilgun Gurel, Ismail Yaz et al.
· Immunology · 0 citations