I. Tzoulaki

Where risk resides

A novel framework leveraging non-causal associations reveals shared pathways linking inflammation and cancer risk

This work proposes a framework for identifying confounders of two non-causally related traits by employing cross-trait pleiotropy analysis to detect genetic loci that affect both traits and multi-trait colocalisation to identify molecular phenotypes mediating these effects.

Identifying protein biomarkers and therapeutic targets in psoriasis through integrative genomic, proteomic and transcriptomic analysis

Plasma proteins are promising biomarkers and potential drug targets in psoriasis. We conducted a two-sample Mendelian randomisation analysis integrating protein quantitative trait loci from UK Biobank and deCODE genetics with a psoriasis GWAS meta-analysis of 36,466 cases. To strengthen causal inference, we performed c...